B01-1：Development of advanced hyphenated techniques coupled with ICP-MS for bio-metals
Yasumitsu Ogra
（Graduate School of Pharmaceutical Sciences, Chiba University）
Lab website / Facebook
The inductively coupled plasma mass spectrometry (ICP-MS) is recently used in the field of life sciences. In order to utilize ICP-MS in the field, it can be expected that the information will increase dramatically by developing several applied analysis methods, not just as a quantitative technique of elements. In this study, the following applications will be developed. Namely, (1) a speciation analysis in cultured cells, (2) a laser ablation coupled with ICP-MS that enables imaging of essential metal/metalloid distribution in tissues, (3) a single particle-ICP-MS method that comprehensively measures all elements in a single cell.
Major publications
*Y. Ogra
“Biology and toxicology of tellurium explored by speciation analysis”
Metallomics, 2017, 9, 435-441
doi: 10.1039/C7MT00022G
Y. Anan, M. Kimura, M. Hayashi, R. Koike, and *Y. Ogra
“Detoxification of selenite to form selenocyanate in mammalian cells”
Chemical Research in Toxicology, 2015, 28, 1803–1814
doi: 10.1021/acs.chemrestox.5b00254
T. Miyayama, D. Hiraoka, F. Kawaji, E. Nakamura, N. Suzuki, and *Y. Ogra
“Roles of COMMD1 in stability and recruitment of the copper-transporting ATPase in mouse hepatoma cell line”
Biochemical Journal, 2010, 429, 53-61
doi: 10.1042/BJ20100223
*Y. Ogra and Y. Anan
“Selenometabolomics: Identification of selenometabolites and specification of their biological significance by complementary use of elemental and molecular mass spectrometry”
Journal of Analytical Atomic Spectrometry, 2009, 24, 1477-1488
doi: 10.1039/B910235C
*Y. Ogra
“Integrated strategies for identification of selenometabolites in animal and plant samples”
Analytical and Bioanalytical Chemistry, 2008, 390, 1685-1689
doi: 10.1007/s00216-007-1796-8