A02-3：Regulation of stem cell differentiation and growth processes viewing from biometal homeostasis and neurodegenerative diseases
Isao Hozumi
（Medical Therapeutics and Molecular Therapeutics, Gifu Pharmaceutical University: Department of Neurology, Gifu University Hospital）
Lab website
Homeostasis of essential biometals is strictly maintained in all creatures, and the disruption of homeostasis could be a risk of developing several diseases. Also in neuronal cells, essential biometals are required for maintaining functions of proteins such as enzymes, and the dyshomeostasis causes neuronal death or aging. Many molecular biological studies such as analyses of variants in causative genes have revealed novel mechanisms or etiologies of familial neurodegenerative diseases. However we have not gained effective therapeutic strategies especially against sporadic neurodegenerative diseases. Our studies and several other studies have indicated that cellular biometal dyshomeostasis is related to neurodegenerative diseases. The purpose of this study is to investigate not only the relationship between disruption of biometal homeostasis and neurodegenerative diseases, but also therapeutic strategies with modulating functions of metal transporters. Our goal is to elucidate the roles of biometal homeostasis on the etiology of sporadic neurodegenerative diseases. The evidences obtained in this study will also contribute to develop novel therapeutics of neurodegenerative diseases.
Major publications
S. Sekine, M. Kaneko, M. Tanaka, Y. Ninomiya, H. Kurita, M. Inden, M. Yamada, Y. Hayashi, T. Inuzuka, J. Mitsui, H. Ishiura, A. Iwata, H. Fujigasaki, H. Tamaki, R. Tamaki, S. Kito, Y. Taguchi, K. Tanaka, N. Atsuta, G. Sobue, T. Kondo, H. Inoue, S. Tsuji, and I. Hozumi
“Functional evaluation of PDGFB-variants in idiopathic basal ganglia calcification, using patient-derived iPS cells”
Scientific Reports, 2019, 9, 5698
doi: 10.1038/s41598-019-42115-y
T. Hirayama, M. Inden, H. Tsuboi, M. Niwa, Y. Uchida, Y. Naka, I. Hozumi and H. Nagasawa
“A Golgi-targeting fluorescent probe for labile Fe(II) to reveal an abnormal cellular iron distribution induced by dysfunction of VPS35”
Chemical Science, 2018, 10, 1514-1521
doi: 10.1039/c8sc04386h
M. Ono, N. Sahara, K. Kumata, B. Ji, R. Ni, S. Koga, D. W. Dickson, J. Q. Trojanowski, V. M-Y. Lee, M. Yoshida, I. Hozumi, Y. Yoshiyama, J. C. van Swieten, A. Nordberg, T. Suhara, M.-R. Zhang, and M. Higuchi
“Distinct binding of PET ligands PBB3 and AV-1451 to tau fibril strains in neurodegenerative tauopathies”
Brain, 2017, 140, 764-780
doi: 10.1093/brain/aww339
T. Ueda, M. Inden, K. Shirai, S. Sekine, Y. Masaki, H. Kurita, K. Ichihara, T. Inuzuka, and I. Hozumi
“The effects of Brazilian green propolis that contains flavonols against mutant copper-zinc superoxide dismutase-mediated toxicity”
Scientific Reports, 2017, 7, 2882
doi: 10.1038/s41598-017-03115-y
M. Kaneko, T. Noguchi, S. Ikegami, T. Sakurai, A. Kakita, Y. Toyoshima, T. Kambe, M. Yamada, M. Inden, H. Hara, K. Oyanagi, T. Inuzuka, H. Takahashi, and I. Hozumi
“Zinc transporters ZnT3 and ZnT6 are downregulated in the spinal cords of patients with sporadic amyotrophic lateral sclerosis”
Journal of Neuroscience Research, 2015, 93, 370-9
doi: 10.1002/jnr.23491